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1996-03-09
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Document 0144
DOCN M9650144
TI [Prognosis of retinal detachment in cytomegalovirus retinitis]
DT 9605
AU Cochereau I; Korobelnik JF; Petit E; Matheron S; Longuet P; Hoang-Xuan
T; Service d'Ophtalmologie, Hopital Bichat-Claude-Bernard, Paris,;
France.
SO J Fr Ophtalmol. 1995;18(10):603-7. Unique Identifier : AIDSLINE
MED/96146813
AB PURPOSE: To evaluate the incidence and the prognosis of retinal
detachment in CMV retinitis in AIDS. To test intravitreal injections of
ganciclovir into the vitreal cavity filled with silicone. METHODS: Among
136 eyes with CMV retinitis, 15 (11%) had retinal detachment. Ten eyes
underwent intraocular surgery with injection of silicone oil, one
extraocular surgery and four eyes were not operated. Later, four eyes
filled with silicone received intravitreal injections of ganciclovir.
RESULTS: At 2 months, the retina was flat in all the operated eyes, with
a visual acuity improved or stabilized in 8 cases (73%). Conversely,
visual acuity was lost in all the unoperated eyes. The 14 intravitreal
injections of ganciclovir performed in four eyes (which received 2, 3, 3
or 6 injections, respectively) were well tolerated. CONCLUSION: Surgery
of retinal detachment in CMV retinitis usually allows the conservation
of ambulatory visual acuity. Its indications must be discussed together
with the patient, the ophthalmologist and the physician. Intravitreal
injections of ganciclovir in vitreal cavity filled with silicone oil are
possible.
DE Adult Antiviral Agents/THERAPEUTIC USE AIDS-Related Opportunistic
Infections/*COMPLICATIONS/SURGERY/ THERAPY Cytomegalovirus
Retinitis/*COMPLICATIONS/SURGERY/THERAPY English Abstract Female
Ganciclovir/THERAPEUTIC USE Human Male Middle Age Prognosis Retinal
Detachment/*ETIOLOGY/SURGERY/THERAPY Risk Factors Silicone
Oils/ADMINISTRATION & DOSAGE Vitrectomy JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).